Stress and need for distressing – An expert discusses the latest research on the impact stress has on inflammatory skin conditions and his thoughts on how this research could change treatment options. the George W. Hambrick Jr., professor and chairman of the department of dermatology, Weill Cornell Medical College, New York say “However, it’s been known for a long time that the nervous system, which processes our stress, has an impact on conditions such as psoriasis. it was gradually realized that such concepts as anxiety, antagonism, exhaustion, frustration, distress, despair, overwork, pre-menstrual tension, over-focusing, confusion, mourning, and fear could all come together in a general broad term, stress. Dr. Granstein said more research needs to be done to further understand the role of the nervous system and stress on inflammatory skin conditions, especially since other factors play a role, including genetics. A dr satsangis we encourage people with inflammatory skin conditions to tell their dermatologist if they believe stress is impacting their condition. They can experiment with stress reduction techniques such as meditation, yoga, or tai chi etc but they should continue their treatment plan as prescribed by their doctors .For distressing our advise for plentiful water intake > 15glasses /d(normal individual), use of yoga and proper homoeopathy will definitely make a person more fit to react normal to aggressive situations and reduction of overall stress. This is a part of psoriasis regime at dr satsangis clinic .
Molecular modalities –a Professor at the Medical University of Vienna in Austria, and one of the lead authors of the study. “Our experiments have revealed that increases in the number of plasmacytoid dendritic cells are important early triggers of the disease while other types of dendritic cells, the Langerhans cells, help to protect the balance of the immune response that is established during inflammation of the skin.” “The changes in the severity of symptoms we have observed related to changes in the composition of dendritic cells most likely impact the balance of inflammatory mediators at the site of disease. It may well be that by inducing favourable compositions of dendritic cells at the early stages of psoriasis we may be able to help reduce the effects of psoriasis by achieving a better balance of these mediators at the site of the disease. Further work is needed before we can say with any certainty if such an approach will lead to a viable clinical treatment for psoriasis.
Food for thought – These tissue immune complex cells ie ratio for langerhans/dendritic cells may be affected by certain herbal solutions like Echinacea ang, berberis aquaifolium ,c arduus marianus ,psorralea cor . etc , proper molecular studies requires to be done in control environment to reveal greater and scientific effect of various plant/floral extracts .
Effect of other medicines on psoriasis -Hypertension and hypertensive drugs –Women& men folk with long-term high blood pressure (hypertension) appear to be at an increased risk for the skin condition psoriasis, and long-term use of beta (β)-blocker medication to treat hypertension may also increase the risk of psoriasis. A higher risk for psoriasis was found among women who regularly used β-blockers for six years or longer. “These findings provide novel insights into the association among hypertension, antihypertensive medications and psoriasis.Some physicians may not consistently examine medications for their contribution to psoriasis flares. However, a careful consideration of the role of medications in psoriasis exacerbation may improve long-term psoriasis control.”
Effect of air pollutants /pollution –psoriasis is a common, long-lasting disease that causes itchy or sore patches of thick, red skin with silvery scales. Environmental contaminants can trigger psoriasis and other autoimmune disorders, and it is thought that a protein called the aryl hydrocarbon receptor (AhR), which senses environmental toxins, could play a role. The findings suggest that stimulation of AhR could improve symptoms and may represent a novel strategy for treating chronic inflammatory skin disorderHowever, our study suggests that molecules found in skin cells also play an important role in the disease.
Lifestyle risks,Smoking and psoriasis risk-the researchers found that current smokers were about 1.9 times more likely to have psoriasis than nonsmokers. Past smokers were nearly 1.4 times more likely to have the condition. The study found a “graded reduction of risk” as time passed after a participant had quit smoking. “Importantly, the investigators showed that the risk of psoriasis increased with the amount of smoking and a reduction in risk of psoriasis was observed with an increase in time from when people quit smoking,” he said. “Smoking is common among patients with psoriasis and extremely common among patients with a variant of psoriasis called ‘palmar-plantar pustular psoriasis,’ which can be severely disabling. Smoking and alcohol use increase your risk of developing psoriasis and may make the disease significantly worse. Heavy drinking may also prevent your treatment from working or your disease from going into remission. This is a particular problem since many people use alcohol or smoking to cope with the tough emotions—such as stress or anxiety—that psoriasis can cause. smoking about doubles a person’s risk of getting psoriasis; the risk increases with the number of cigarettes smoked per day, and is higher in women than men. Dr. Naldi points to nicotine as a possible culprit in altering the immune system and possibly skin cell growth, as well as directly affecting skin inflammation. Smoking and alcohol may also be associated with the same psychosocial factors that may drive psoriasis, such as stress, worry and poor coping skills.