Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. As a result, white patches appear on the skin in different parts of the body. Similar patches also appear on both the mucous membranes (tissues that line the inside of the mouth and nose) and the retina (inner layer of the eyeball). The hair that grows on areas affected by vitiligo sometimes turns whiteVitiligo is earmarked by patches of depigmented skin in a localized to generalized distribution. The course of the disease is unpredictable. Vitiliginous skin lesions may remain stable or slowly progress for years. In some instances, however, patients undergo rapid, complete depigmentation in 1 or 2 years Up to now, mostly has a chronic and progressive course. The disorder may be part of a polygenic, multifactorial transmitted disease with an increased disposition to autoimmune disorders, which should be screened for.